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Related Experiment Videos

Recurrent septicemias with Enterococcus faecium

H A Elsner1, D Drews, M Burdelski

  • 1Institut für Medizinische Mikrobiologie und Immunologie, Abt. für Krankenhaushygiene, Universitätsklinik Hamburg-Eppendorf, Germany.

Infection
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

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A liver transplant patient experienced repeated infections from the same ampicillin-resistant Enterococcus faecium strain for nine months. This highlights the long-term colonization risk of multidrug-resistant enterococci in transplant recipients.

Area of Science:

  • * Infectious Diseases
  • * Transplant Surgery
  • * Microbiology

Background:

  • * Orthotopic liver transplantation is a complex procedure for patients with conditions like extrahepatic biliary atresia.
  • * Post-transplant infections pose a significant risk, particularly from multidrug-resistant organisms.
  • * Enterococcus faecium is a common cause of healthcare-associated infections.

Observation:

  • * A 17-year-old male liver transplant recipient developed recurrent infections over nine months.
  • * Ampicillin-resistant Enterococcus faecium was repeatedly isolated from blood, bile, stool, and wound abscess.
  • * Pulsed-field gel electrophoresis confirmed the clonal identity of all E. faecium isolates.

Findings:

  • * The same strain of ampicillin-resistant Enterococcus faecium persisted and caused repeated infections for a nine-month period.

Related Experiment Videos

  • * This represents a prolonged colonization and reinfection cycle with a multidrug-resistant pathogen in a transplant patient.
  • * The study documents an unusually long duration of infection by a single E. faecium strain.

    • Implications:

    • * Multidrug-resistant enterococci can colonize and repeatedly infect liver transplant recipients for extended durations.
    • * Careful consideration of preoperative antibiotic therapy is crucial to avoid selecting for resistant organisms like E. faecium.
    • * Long-term surveillance and targeted antimicrobial strategies are essential for managing infections in immunocompromised transplant patients.