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Infantile-onset multisystem inflammatory disease: a differential diagnosis of systemic juvenile rheumatoid arthritis
C L De Cunto1, D I Liberatore, J L San Román
1Pediatric Rheumatology Section, Hospital Italiano, Buenos Aires, Argentina.
Insights
We report on four children with a rare infantile-onset multisystemic inflammatory disease presenting with rash, fever, arthritis, and organ enlargement. Joint X-rays revealed characteristic bone abnormalities, and one patient developed chondrosarcoma.
Area of Science:
- Pediatrics
- Rheumatology
- Genetics
Background:
- Neonatal-onset multisystemic inflammatory diseases are rare and can present with diverse symptoms.
- Early diagnosis and characterization are crucial for appropriate management.
Abstract:
We describe four unrelated children with neonatal maculopapular rash, fever, arthritis, hepatosplenomegaly, lymphadenopathy, eye involvement, and neurologic symptoms. Radiographs of the joints were surprisingly similar, showing an abnormal epiphyseal and metaphyseal appearance. These clinical and radiologic findings allowed us to include these children in a very peculiar syndrome described as infantile-onset multisystemic inflammatory disease. A chondrosarcoma developed in one of our patients.