Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Auditory evoked potentials, clinical vs. research applications

N Boutros1, H Nasrallah, R Leighty

  • 1Department of Psychiatry (116A), Yale University, West Haven VA Medical Center, CT 06516, USA.

Psychiatry Research
|March 24, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abstracts International Scientific Day on Oxidative Stress, Aging, and Age-Related Diseases.

La Tunisie medicale·2026
Same author

Resolution of selective fetal growth restriction after laser surgery for twin-to-twin transfusion syndrome can be predicted by predisease growth discordance.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Trimester-specific reference intervals for thyroid function parameters in pregnant Caucasian women using Roche platforms: a prospective study.

Journal of endocrinological investigation·2023
Same author

Outcomes Following Hypofractionated Stereotactic Radiotherapy to the Cavity After Surgery for Melanoma Brain Metastases.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

MAPlex - A massively parallel sequencing ancestry analysis multiplex for Asia-Pacific populations.

Forensic science international. Genetics·2019
Same author

Use of aspirin, other nonsteroidal anti-inflammatory drugs and acetaminophen and risk of endometrial cancer: the Epidemiology of Endometrial Cancer Consortium.

Annals of oncology : official journal of the European Society for Medical Oncology·2018

Abnormal auditory evoked potentials (EPs) in schizophrenia patients, particularly N100, P200, and P300 amplitudes, were replicated. These findings suggest EPs may aid differential diagnosis when considering patient probability and misclassification costs.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Abnormal auditory evoked potentials (EPs) are increasingly observed in schizophrenia patients.
  • Despite extensive research, EPs have not yet achieved widespread clinical utility for diagnosis.

Purpose of the Study:

  • To replicate auditory EPs findings in a large schizophrenia cohort.
  • To explore the potential of EPs as supplementary diagnostic tools in differential diagnosis.

Main Methods:

  • Five groups studied: paranoid/disorganized schizophrenics, schizoaffective, bipolar, and normal controls.
  • Auditory EPs recorded using an 'Odd Ball' paradigm.
  • Classification and Regression Trees (CART) analyzed EP amplitudes for subject classification.

Related Experiment Videos

Main Results:

  • Significantly decreased N100 amplitudes in disorganized/undifferentiated schizophrenics compared to bipolar or normal subjects.
  • Reduced P200 amplitudes observed in paranoid, disorganized/undifferentiated schizophrenics, and schizoaffective groups versus controls.
  • Lower P300 amplitudes in disorganized/undifferentiated and paranoid schizophrenics compared to normal controls.

Conclusions:

  • Study data align with existing literature on decreased N100, P200, and P300 amplitudes in schizophrenia.
  • Clinical utility of EPs depends on the specific clinical context, including prior diagnostic probability and misclassification costs.