Cross-linking of actin and fibrin by fibrin-stabilizing factor

Fibrin-stabilizing factor is known to cross-link fibrin monomers. This study was undertaken to explore whether a similar interaction might occur between actin and fibrin. Purified actin and fibrinogen were labeled with 131I and 125I, respectively. The interaction of actin and fibrin, under different conditions, was evaluated by gel electrophoresis. The data show that actin and fibrin are cross-linked in the presence of fibrin-stabilizing factor.