Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Right ventricular performance during ischemia: an anatomic and hemodynamic analysis

H Brooks, R Holland, J Al-Sadir

    The American Journal of Physiology
    |October 1, 1977
    PubMed
    Summary

    Right ventricular (RV) contractile function is significantly impaired by anteroseptal and inferoseptal myocardial infarction, but not anterolateral infarction. This highlights regional differences in RV response to coronary artery occlusion.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A coaching intervention to improve physician mental health and well-being during COVID-19.

    Occupational medicine (Oxford, England)·2025
    Same author

    Cerebral aneurysm surgical training in the neuroendovascular era and its impact on the production of comfortable aneurysm surgeons.

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2025
    Same author

    Development and validation of a questionnaire to assess owner and canine quality-of-life and treatment satisfaction in canine allergic dermatitis.

    Veterinary dermatology·2024
    Same author

    Medicalisation of vaping in the UK? E-cigarette users' perspectives on the merging of commercial and medical routes to vaping.

    Perspectives in public health·2023
    Same author

    Higher Incidence of Unruptured Intracranial Aneurysms among Black and Hispanic Women on Screening MRA in Large Urban Populations.

    AJNR. American journal of neuroradiology·2023
    Same author

    Evaluation of a training programme for Pharmacist Independent Prescribers in a care home medicine management intervention.

    BMC medical education·2022

    Area of Science:

    • Cardiovascular Physiology
    • Myocardial Infarction Research
    • Cardiac Electrophysiology

    Background:

    • Understanding right ventricular (RV) contractile responses to myocardial infarction is crucial for clinical outcomes.
    • Previous studies have not fully elucidated the regional differences in RV dysfunction following specific coronary artery occlusions.

    Purpose of the Study:

    • To characterize the RV contractile responses to infarction in distinct myocardial regions: anteroseptal, anterolateral, and inferoseptal.
    • To investigate the impact of localized infarction on RV pressure, flow, and contractility parameters.

    Main Methods:

    • Utilized a porcine model to study coronary architecture via multicolor vinyl casts.
    • Assessed ventricular pressure and flow data in real-time following ligation of specific coronary arteries (anterior descending, left circumflex, posterior descending).

    Related Experiment Videos

  • Quantified myocardial infarct size and evaluated RV end-diastolic pressure (EDP) and pressure development (dP/dt).

    • Main Results:

    • Anterolateral infarction led to decreased RV flow but no significant changes in RV EDP or contractility.
    • Anteroseptal and inferoseptal infarctions caused significant alterations in RV contractile parameters and elevated RVEDP.
    • Inferoseptal infarction, with additional right coronary occlusion, exacerbated RV contractile abnormalities and induced tricuspid insufficiency in some animals.

    Conclusions:

    • RV contractile state is primarily depressed in anteroseptal and inferoseptal infarctions, unlike anterolateral infarction.
    • Regional myocardial infarction severity dictates the extent and nature of RV contractile dysfunction.
    • Further research into RV protection strategies for specific infarct locations is warranted.