Related Experiment Video
Updated: Aug 4, 2026
08:13
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Contrast echocardiography displays increased subendocardial perfusion after nitroglycerin administration
R H Chandwaney1, E Zajac, J Saldivar
1Department of Medicine, University of Illinois, Chicago 60612-7323, USA.
Summary
Nitroglycerin improves blood flow to the heart's subendocardium. Contrast echocardiography revealed enhanced myocardial perfusion after nitroglycerin administration in patients.
Area of Science:
- Cardiology
- Medical Imaging
Background:
- Nitroglycerin's antianginal effect may involve coronary blood flow redistribution to the subendocardium.
- Contrast echocardiography is a tool for assessing regional myocardial perfusion.
Purpose of the Study:
- To evaluate the impact of nitroglycerin on myocardial transmural perfusion using contrast echocardiography in humans.
Main Methods:
- Nine patients received 300 microg of intracoronary nitroglycerin before coronary angiography.
- Contrast echocardiographic studies were conducted pre- and post-nitroglycerin administration.
- Videodensitometry analyzed subendocardial and subepicardial opacification.
Main Results:
- Subendocardial > subepicardial opacification increased significantly post-nitroglycerin (6/13 to 11/13 patients, p <0.05).
- This effect was more pronounced during diastole (9/13 to 13/13 patients, p <0.05).
Conclusions:
- Contrast echocardiography confirmed increased subendocardial perfusion following nitroglycerin administration.
- Nitroglycerin enhances myocardial perfusion, particularly to the subendocardium.
More Related Videos
Related Concept Videos
01:17Imaging Studies for Cardiovascular System I:Echocardiography
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion, evaluates...
01:20Imaging Studies for Cardiovascular System II:Types of Echocardiography
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
01:28Imaging Studies for Cardiovascular System V: CT
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...