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The Eugene M. Landis Award Lecture 1996. Delivery of molecular and cellular medicine to solid tumors
1Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
Abstract:
To reach cancer cells in a tumor, a blood-borne therapeutic molecule or cell must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically and then integrate the resulting information in a unified theoretical framework. This paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiologic barriers in solid tumors and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.
Insights
Researchers are analyzing the journey of cancer therapeutics into tumors to overcome physical barriers. This work aims to improve cancer detection and treatment strategies by understanding tumor physiology.
Area of Science:
- Oncology
- Biomedical Engineering
- Cancer Biology
Background:
- Solid tumors present significant physiologic barriers hindering therapeutic delivery.
- Effective cancer treatment requires overcoming these barriers for molecules and cells to reach cancer cells.