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Ethical problems in psychiatric research

N S Lehrman1, V H Sharav

  • 1Yale University Medical School, USA.

Journal of Mental Health Administration
|April 1, 1997
PubMed
Summary
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This article questions the ethics of psychiatric research on patients with impaired judgment, particularly when worsening symptoms or withholding treatment. It calls for stronger safeguards in clinical trials involving vulnerable populations.

Area of Science:

  • Neuroscience and Psychiatry
  • Bioethics and Research Ethics

Background:

  • Experiments on psychiatric patients, especially those with schizophrenia, raise ethical concerns due to impaired capacity for informed consent.
  • Current research practices may involve exacerbating psychotic symptoms or withholding treatment from vulnerable patient-subjects.

Purpose of the Study:

  • To critically evaluate the morality and ethical value of experiments conducted on psychiatric patient-subjects.
  • To examine the adequacy of existing safeguards, including federal regulations, peer review, and institutional review board oversight.

Main Methods:

  • Analysis of experimental studies involving exacerbation of psychotic symptoms in schizophrenia patients.
  • Review of ethical principles and guidelines, including the American College of Neuropsychopharmacology's draft statement.
Keywords:
Biomedical and Behavioral ResearchMental Health Therapies

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  • Examination of the concept and application of informed consent in psychiatric research.

    • Main Results:

    • Significant ethical questions arise regarding the exacerbation of symptoms and the use of placebo controls in vulnerable populations.
    • Concerns exist about the adequacy of informed consent processes and the transparency of institutional review boards.
    • Existing federal regulations and peer review mechanisms may be insufficient to protect psychiatric patient-subjects.

    Conclusions:

    • There is a pressing need to re-evaluate the ethical standards and safeguards in psychiatric research.
    • Recommendations are proposed for enhancing protection and minimizing risks for individuals participating in clinical trials.
    • Implications for mental health policy require careful consideration to ensure patient welfare.