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Related Experiment Videos

Brodifacoum intoxication with marijuana smoking

F G La Rosa1, S H Clarke, J B Lefkowitz

  • 1Department of Pathology and the Webb-Waring Institute for Biomedical Research, Denver, Colo 80262, USA.

Archives of Pathology & Laboratory Medicine
|January 1, 1997
PubMed
Summary

A teenager experienced prolonged bleeding issues after smoking marijuana laced with brodifacoum, a potent anticoagulant. This case highlights super-warfarin intoxication linked to drug abuse, requiring clinical awareness for persistent coagulopathy.

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Area of Science:

  • Toxicology
  • Hematology
  • Pharmacology

Background:

  • Super-warfarin rodenticides, like brodifacoum, are known for their prolonged anticoagulant effects.
  • Drug abuse, including the use of illicit substances, presents complex clinical challenges.
  • Vitamin K1-dependent coagulation factors are crucial for hemostasis and are targeted by anticoagulants.

Observation:

  • A 17-year-old male with a history of substance abuse presented with persistent coagulopathy.
  • The patient reported smoking marijuana mixed with brodifacoum.
  • The coagulopathy lasted for over a year, indicating a severe and prolonged toxic effect.

Findings:

  • This is the first reported case linking marijuana smoking with brodifacoum to super-warfarin intoxication.

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  • The combination led to a prolonged vitamin K1-dependent coagulopathy.
  • Standard anticoagulant reversal protocols may require extended duration or alternative strategies.

    • Implications:

    • Clinicians and pathologists should consider super-warfarin intoxication in patients with a history of drug abuse and unexplained coagulopathy.
    • Awareness of novel routes of exposure, such as smoking contaminated marijuana, is critical.
    • Further research may be needed to understand the pharmacokinetics and management of such co-exposures.