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Updated: Jul 31, 2026
05:37
Intravitreous Injection for Establishing Ocular Diseases Model
Published on: October 1, 2007
Intravitreal injections by a Dermojet syringe
Annals of Ophthalmology
|June 1, 1977
Summary
The Dermojet device, used for accidental intraocular injection, showed no adverse effects in experimental rabbit eye injections. Further research is needed before human use.
Area of Science:
- Ophthalmology
- Medical Devices
- Pharmacology
Background:
- The Dermojet is a spring-loaded device designed for high-velocity microspray injections.
- An accidental intraocular injection of triamcinolone acetonide occurred with a Dermojet syringe.
Purpose of the Study:
- To evaluate the safety and effects of intravitreal injections using the Dermojet device in an animal model.
- To assess the potential of the Dermojet for ocular drug delivery.
Main Methods:
- Intravitreal injections were performed in 7 rabbit eyes using the Dermojet syringe.
- Normal saline was used as the vehicle in 6 eyes, and India ink in one eye.
- Clinical and histopathological examinations were conducted to assess effects.
Main Results:
- No irreversible clinical or histopathological effects were observed in the rabbit eyes post-injection.
- The Dermojet device demonstrated a lack of immediate adverse effects in this experimental setting.
Conclusions:
- The Dermojet device may have potential for intravitreal injections, but requires further modification and animal experimentation.
- Current evidence suggests the Dermojet should not be used for human ocular injections at this time.
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