Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic markers in primary open-angle glaucoma

E Abecia1, B Martínez-Jarreta, Y Casalod

  • 1Department of Ophthalmology, 'Miguel Servet' Hospital, Zaragoza, Spain.

International Ophthalmology
|January 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying the Basal Insulin Treatment Preferences of People Living in Canada With Type 2 Diabetes When Glycemic Control and Cost Are Held Constant: A Discrete Choice Experiment.

Canadian journal of diabetes·2026
Same author

[Translated article] Bioethical Conflicts in Current Dermatology: A Narrative Review.

Actas dermo-sifiliograficas·2024
Same author

Perception of patients with retinal pathology on aspects of visual function and their management.

Archivos de la Sociedad Espanola de Oftalmologia·2024
Same author

Tetanus prophylaxis in horses: guidelines for New Zealand and Australia based on a critical appraisal of the evidence.

New Zealand veterinary journal·2024
Same author

Bioethical Conflicts in Current Dermatology: A Narrative Review.

Actas dermo-sifiliograficas·2024
Same author

The novel Mechanical Ventilator Milano for the COVID-19 pandemic.

Physics of fluids (Woodbury, N.Y. : 1994)·2021

Researchers explored genetic markers for Primary Open-Angle Glaucoma (POAG). A significant association was found between POAG patients and the Acid Phosphatase ACP*C allele, suggesting a potential gene localization.

Area of Science:

  • Genetics
  • Ophthalmology
  • Molecular Biology

Background:

  • Primary Open-Angle Glaucoma (POAG) is a leading cause of irreversible blindness worldwide.
  • The genetic basis of POAG remains incompletely understood, necessitating further research into potential genetic contributors.
  • Identifying specific genetic markers associated with POAG is crucial for understanding disease mechanisms and developing targeted therapies.

Purpose of the Study:

  • To investigate potential associations between various genetic markers and the occurrence of Primary Open-Angle Glaucoma (POAG).
  • To identify specific genetic variations that may predispose individuals to developing POAG.
  • To lay the groundwork for the localization of genes implicated in POAG pathogenesis.

Main Methods:

  • Genetic typing of multiple markers including Transferrin, Group Specific Component, G1m allotypes, Adenylate Kinase, Adenosine Deaminase, Glyoxalase I, Acid Phosphatase, HLA-DQA1, and D1S80.

Related Experiment Videos

  • Comparison of genetic marker frequencies between 84 unrelated POAG patients and a control group of healthy individuals.
  • Statistical analysis, including chi-squared tests, to determine the significance of observed associations.

    • Main Results:

    • No significant genetic associations were detected for most markers tested.
    • A strong and statistically significant association was identified between POAG patients and the Acid Phosphatase (ACP*C) allele (chi-squared = 32.86; p < 0.0001).
    • This finding suggests a specific role for the Acid Phosphatase gene or linked loci in POAG susceptibility.

    Conclusions:

    • The strong association with the Acid Phosphatase ACP*C allele provides a significant clue for POAG gene localization.
    • Given that the Acid Phosphatase gene is located on chromosome 2p23, this finding represents a potential step towards pinpointing specific POAG-related genes.
    • Further studies are warranted to confirm this association and explore the functional implications of Acid Phosphatase in glaucoma pathogenesis.