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Related Experiment Videos

Naltrexone and cyclazocine. A controlled treatment study

L S Brahen, T Capone, V Wiechert

    Archives of General Psychiatry
    |October 1, 1977
    PubMed
    Summary

    Naltrexone showed fewer side effects than cyclazocine in a study comparing these opioid antagonists. Naltrexone side effects were comparable to placebo, while cyclazocine side effects increased.

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    Area of Science:

    • Pharmacology
    • Clinical Trials
    • Drug Safety

    Background:

    • Opioid antagonists like cyclazocine and naltrexone are used in managing opioid dependence.
    • Understanding their induction side effect profiles is crucial for patient management.

    Purpose of the Study:

    • To compare the induction side effects of cyclazocine and naltrexone.
    • To evaluate the tolerability of these agents during treatment initiation.

    Main Methods:

    • Double-blind, placebo-controlled studies were conducted.
    • Forty patients were enrolled, with 20 receiving cyclazocine and 20 receiving naltrexone.
    • A twice-daily dosage regimen was employed.

    Main Results:

    • Naltrexone demonstrated significantly fewer side effects compared to cyclazocine.
    • Naltrexone's side effects were comparable to placebo levels.
    • Cyclazocine treatment led to an increase in side effects, even after a placebo phase.
    • No patients discontinued naltrexone due to side effects, unlike three patients on cyclazocine.

    Conclusions:

    • Naltrexone is better tolerated than cyclazocine regarding induction side effects.
    • The findings support the clinical use of naltrexone over cyclazocine for initial treatment phases due to improved tolerability.

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