Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Features of autoantigens

W H Reeves¹, M Satoh

¹Division of Rheumatology and Immunology, Thurston Arthritis Research Center, USA.

Molecular Biology Reports

|January 1, 1996

Summary

This summary is machine-generated.

Autoantibodies are key diagnostic markers for systemic autoimmune diseases like lupus. Research suggests altered autoantigen structure may explain restricted autoantibody responses and disease specificity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Expandable metallic stent therapy for SVC syndrome--effects on local venous pressure, vascular diameter, symptoms, and these correlations].

Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992

Same author

Two children with bromate intoxication due to ingestion of the second preparation for permanent hair waving.

Acta paediatrica Japonica : Overseas edition·1992

Same author

Agranulocytosis associated with pyrithioxine therapy.

American journal of hematology·1992

Same author

[Respiratory control in diffuse interstitial lung disease].

Nihon Kyobu Shikkan Gakkai zasshi·1992

Same author

[Small cell carcinoma of the bladder. Small cell lung cancer-associated ganglioside (Fuc GM1) expression].

Nihon Hinyokika Gakkai zasshi. The japanese journal of urology·1992

Same author

Identification and characterization of the alpha 2D-adrenoceptor subtype in single cells prepared from guinea pig tracheal smooth muscles.

Japanese journal of pharmacology·1992

Same journal

Neuroprotective potential of resveratrol in Parkinson, Huntington, amyotrophic lateral sclerosis, and multiple sclerosis: a comprehensive review.

Molecular biology reports·2026

Same journal

IL-22 modulates STAT3/β-catenin/let-7a signaling and hepatic granulomas in Schistosoma mansoni infection: versus praziquantel and combination treatment.

Molecular biology reports·2026

Same journal

Stem cell-based regenerative therapies for non-ischemic cardiomyopathy: mechanistic insights, clinical evidence, and future directions.

Molecular biology reports·2026

Same journal

A novel DREB transcription factor enhances salt tolerance in peanut (Arachis hypogaea L.) through upregulation of AhP5CR and AhBADH, leading to increased osmolyte accumulation.

Molecular biology reports·2026

Same journal

Retraction Note: 2-Hydroxylethyl methacrylate (HEMA), a tooth restoration component, exerts its genotoxic effects in human gingival fibroblasts trough methacrylic acid, an immediate product of its degradation.

Molecular biology reports·2026

Same journal

Development of a CRISPR/dCas9-based membrane-assisted colorimetric assay for detection of high-risk HPV16 and HPV18: a proof-of-concept study.

Molecular biology reports·2026

See all related articles

Area of Science:

Immunology
Pathogenesis of Autoimmune Diseases

Background:

Autoantibodies are crucial diagnostic markers for systemic autoimmune diseases, including Systemic Lupus Erythematosus (SLE).
The specificity of autoantibodies, with some being pathognomonic for SLE (e.g., anti-Sm) while others indicate different autoimmune subsets, remains poorly understood.
Most autoantigens in systemic autoimmunity are nucleoprotein complexes, leading to responses against multiple components.

Purpose of the Study:

To investigate the features of autoantigens that may explain the specific patterns of autoantibody recognition in SLE and other systemic autoimmune diseases.
To explore the mechanisms underlying intermolecular and intrastructural spreading of autoimmunity.
To understand why autoantibodies target restricted antigenic determinants, often functional sites.

Main Methods:

Related Experiment Videos

Review and analysis of existing research on autoantigens and autoantibodies in systemic autoimmunity.
Examination of experimental models of autoimmunity to explore potential mechanisms of autoantigen alteration.
Focus on nucleoprotein complexes as key autoantigens.

Main Results:

Autoantigens are often multicomponent nucleoprotein complexes, leading to the production of autoantibodies against several components simultaneously.
The mechanisms regulating the spreading of autoimmunity are not well-defined.
Antigenic determinants recognized by autoantibodies are restricted and frequently correspond to active or functional domains.

Conclusions:

Altered autoantigen structure, potentially due to abnormal protein interactions, hapten binding, or altered degradation, may explain restricted autoantibody spreading.
Investigating autoantigen structure modifications offers a promising avenue for understanding the pathogenesis of systemic autoimmune diseases.
Further research into autoantigen structure is warranted to elucidate disease-specific autoantibody responses.