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Flutamide photosensitivity

D Leroy1, A Dompmartin, C Szczurko

  • 1Department of Dermatology of Caen, France.

Photodermatology, Photoimmunology & Photomedicine
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

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Flutamide, an antiandrogen for prostate cancer, can cause sun sensitivity. This drug likely triggers a photo-allergic reaction in the UVA spectrum, leading to skin issues.

Area of Science:

  • Dermatology
  • Pharmacology
  • Oncology

Background:

  • Flutamide is a non-steroidal antiandrogen prescribed for advanced prostate cancer.
  • Hepatotoxicity is a known side effect; however, photosensitivity is less common but reported.

Observation:

  • A patient developed a sun-exposed skin eruption during flutamide treatment.
  • The eruption resolved upon flutamide discontinuation and reappeared upon rechallenge.
  • Photopatch tests were negative, but the patient's UVA minimal erythema dose (MED) decreased significantly during flutamide exposure.

Findings:

  • The patient's photosensitivity reaction correlated with flutamide treatment and rechallenge.
  • The action spectrum for flutamide-induced photosensitivity appears to be within the UVA range.

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  • The mechanism is likely photo-allergic, as suggested by the clinical presentation and UVA MED reduction.

    • Implications:

    • Clinicians should be aware of flutamide-induced photosensitivity, potentially mediated by UVA radiation.
    • This case highlights the importance of considering drug-induced phototoxicity in patients on flutamide.
    • Further investigation into the photo-allergic potential of flutamide is warranted.