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Related Experiment Videos

Screening tests in acute porphyria

J M Lamon, B C Frykholm, D P Tschudy

    Archives of Neurology
    |November 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This study compared two screening tests for urinary porphobilinogen (PBG) in acute porphyria. Both the Watson-Schwartz and Hoesch tests effectively detect elevated PBG levels, aiding in rapid diagnosis.

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    Area of Science:

    • Clinical Chemistry
    • Biochemical Diagnostics
    • Urine Analysis

    Background:

    • Acute porphyrias are rare metabolic disorders characterized by the overproduction and excretion of porphyrin precursors.
    • Urinary porphobilinogen (PBG) is a key biomarker for diagnosing acute porphyric attacks.
    • Rapid and accurate screening methods are crucial for timely clinical intervention.

    Purpose of the Study:

    • To compare the diagnostic performance of two common screening tests for urinary porphobilinogen (PBG).
    • To evaluate the sensitivity and practicality of the Watson-Schwartz and Hoesch tests in patients with suspected acute porphyria.

    Main Methods:

    • Comparison of Watson-Schwartz and Hoesch screening tests against quantitative PBG measurements.
    • Analysis of 191 24-hour urine specimens from 74 patients with suspected or confirmed acute porphyria.

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  • Assessment of test positivity at specific PBG concentration thresholds (mg/liter).

    • Main Results:

    • Both Watson-Schwartz and Hoesch tests demonstrated positivity at urinary PBG concentrations above 9 mg/liter.
    • A positive pink color reaction was rarely observed below 3 mg/liter PBG for both methods.
    • The Hoesch test was identified as a simple and rapid screening procedure.

    Conclusions:

    • The Watson-Schwartz and Hoesch tests are valuable tools for detecting elevated urinary PBG during acute porphyric episodes.
    • Positive results from either screening test necessitate confirmation through quantitative PBG analysis.
    • These screening methods aid in the early identification of acute porphyria, guiding further diagnostic workup.