Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Potential molecular targets for manipulating the radiation response

A Maity1, G D Kao, R J Muschel

  • 1Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, USA.

International Journal of Radiation Oncology, Biology, Physics
|February 1, 1997
PubMed
Summary

Manipulating molecular pathways like DNA repair, apoptosis, and cell-cycle arrest can alter the radiation response. Targeting specific molecules may enhance radiosensitivity or reduce side effects from radiation therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and molecular characterization of extended-spectrum β-lactamase (ESBL) producing <i>Escherichia coli</i> isolated from dogs suffering from diarrhea in and around Kolkata.

Iranian journal of veterinary research·2022
Same author

Concurrent thyrolipomatosis and thymolipoma in a patient with myasthenia gravis: a case report and review of the literature.

Annals of the Royal College of Surgeons of England·2021
Same author

Participation of Phosphatidylinositol-3 Kinase Signalling in Human Chorionic Gonadotropin, Bovine Insulin (B-Insulin) and Human-Insulin-Like Growth Factor-I Induced Oocyte Maturation and Steroidogenesis in the Grey Mullet, <i>Mugil Cephalus</i>.

Acta endocrinologica (Bucharest, Romania : 2005)·2021
Same author

Safe surgical tracheostomy in patients with COVID-19: key clinical considerations.

Annals of the Royal College of Surgeons of England·2021
Same author

DUAL ACTION OF ARECOLINE ON ADRENAL FUNCTION AND GLUCOSE-GLYCOGEN HOMEOSTASIS IN METABOLIC STRESS IN MICE.

Acta endocrinologica (Bucharest, Romania : 2005)·2019
Same author

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.

Nature communications·2018

Area of Science:

  • Molecular biology
  • Radiation oncology
  • Cancer research

Background:

  • Ionizing radiation induces DNA damage, apoptosis, and cell-cycle arrest.
  • Understanding these molecular events offers targets for manipulating radiation response.

Purpose of the Study:

  • To explore molecular targets for enhancing radiosensitivity.
  • To investigate strategies for reducing radiation-induced side effects.

Main Methods:

  • Review of recent advances in molecular radiobiology.
  • Identification of key molecular pathways involved in radiation response.

Main Results:

  • Inactivating Ras or DNA repair components may increase radiosensitivity.
  • Promoting apoptosis could be beneficial for tumor cell death.

Related Experiment Videos

  • Inhibiting apoptosis in normal tissues may reduce side effects like pneumonitis.
  • Blocking genes like transforming growth factor beta may prevent fibrosis.
  • Abolishing G2 delay could enhance radiosensitivity, particularly in p53-mutated cells.

    • Conclusions:

    • Molecular manipulation offers promising strategies to optimize radiation therapy.
    • Targeting specific pathways can improve treatment efficacy and reduce toxicity.