Role of eicosanoids in the postischemic shock development

Using premedication with indomethacin and/or quercetin, the role of the eicosanoids as one of the main shock mediators has been demonstrated in anesthetized dogs using a model of postischemic shock. Hemodynamic disturbances were correlated with an increment in eicosanoids blood levels both in time and value courses. The results testify to the vascular endothelium injury in all investigated regions. This event might be a starting point of the disturbances in balance between a necessity and real flow in working organs under shock-like states. Therefore, a damage in endotheliocytes function is the first and may be a leading factor in the development of postischemic disturbances of circulation. Pretreatment with the inhibitors of eicosanoids biosynthesis prevented the reperfusion-evoked hemodynamic disturbances.