Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathogenesis of essential hypertension--present views

W Januszewicz1, J Chodakowska

  • 1Department of Hypertension and Angiology, Medical Academy, Warszawa, Poland.

Polish Journal of Pharmacology
|January 1, 1996
PubMed
Summary

This review explores essential hypertension pathogenesis, focusing on sympathetic activity, natriuretic peptide, endothelins, nitric oxide, endothelial dysfunction, and insulin resistance. Genetics offers the most promising research direction for understanding hypertension.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-omic cross-sectional cohort study of pre-malignant Barrett's esophagus reveals early structural variation and retrotransposon activity.

Nature communications·2022
Same author

An international survey of polypectomy training and assessment.

Endoscopy international open·2017
Same author

Genetic influence on blood pressure and lipid parameters in a sample of Polish twins.

Blood pressure·2003
Same author

Dopamine and dopa urinary excretion in patients with pheochromocytoma--diagnostic implications.

Blood pressure·2002
Same author

Immunomorphological studies and cytometric DNA ploidy in diagnostics of pheochromocytoma.

Polish journal of pathology : official journal of the Polish Society of Pathologists·2000
Same author

Incidence and clinical relevance of RET proto-oncogene germline mutations in pheochromocytoma patients.

Journal of hypertension·2000

Area of Science:

  • Cardiology and Pathophysiology
  • Endocrinology

Background:

  • Essential hypertension pathogenesis involves complex multifactorial processes.
  • Understanding these pathways is crucial for developing effective treatments.

Purpose of the Study:

  • To review current research on essential hypertension pathogenesis.
  • To highlight key factors including neurohormonal, vascular, and metabolic elements.
  • To identify promising areas for future research.

Main Methods:

  • Literature review of modern research on essential hypertension.
  • Synthesis of findings on sympathetic activity, neuropeptide Y, atrial natriuretic peptide, endothelins, and nitric oxide.
  • Discussion of endothelial dysfunction and hyperinsulinemia/insulin resistance.

Related Experiment Videos

Main Results:

  • Sympathetic activity, neuropeptide Y, atrial natriuretic peptide, endothelins, and nitric oxide play significant roles.
  • Endothelial dysfunction is implicated as both a cause and consequence of hypertension.
  • Hyperinsulinemia and insulin resistance are key interrelated pathogenetic factors.

Conclusions:

  • Essential hypertension involves a complex interplay of neurohormonal, vascular, and metabolic factors.
  • Genetic studies represent the most promising avenue for future research into hypertension etiology.