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5-HT3 receptors and central effects of ethanol
1Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Abstract:
This review discusses recent experimental findings in serotonin-3 (5-HT3) receptors and ethanol (EtOH) research. The role of these receptors in central effects of EtOH including the effects of 5-HT3 agonists and antagonists on EtOH intake, rewarding and aversive properties of EtOH and EtOH interoceptive cue is reviewed. It is now recognized that 5-HT3 receptors while involved in EtOH intake, EtOH tolerance and withdrawal and rewarding mechanisms do not play an important role in aversive effects of EtOH and EtOH discriminative stimulus. 5-HT3 receptors involved in EtOH consumption are supposedly located on dopaminergic neurons in the nucleus accumbens.