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Related Experiment Videos

Intercellular adhesion molecule-1 in proliferative vitreoretinopathy

G A Limb1, A H Chignell, C J Cole

  • 1Department of Immunology, St. Thomas' Hospital, UMDS, London, England.

Investigative Ophthalmology & Visual Science
|April 1, 1997
PubMed
Summary

Vitreous soluble intercellular adhesion molecule (sICAM-1) is elevated in eyes with proliferative vitreoretinopathy (PVR) following retinal detachment, especially after prior surgery. This suggests an impaired inflammatory response in PVR development.

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Inflammation Biology

Background:

  • Proliferative vitreoretinopathy (PVR) is a major cause of failure after rhegmatogenous retinal detachment (RRD) surgery.
  • The role of soluble intercellular adhesion molecule-1 (sICAM-1) in the pathogenesis of PVR is not fully understood.

Purpose of the Study:

  • To measure vitreous sICAM-1 levels in eyes with RRD, with or without PVR.
  • To investigate the relationship between vitreous sICAM-1 levels and previous retinal surgery, PVR duration, and severity.

Main Methods:

  • Vitreous samples were analyzed for sICAM-1 using enzyme-linked immunosorbent assay.
  • Included were eyes with PVR (n=28), uncomplicated RRD (n=35), macular holes (n=10), and cadaveric controls (n=12).

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Main Results:

  • Elevated vitreous sICAM-1 was observed in eyes with PVR compared to RRD alone or controls.
  • In patients with prior surgery, higher sICAM-1 levels were found in the PVR group.
  • Raised sICAM-1 in PVR correlated with previous vitrectomy and longer disease duration, but not PVR grade.

Conclusions:

  • Elevated vitreous sICAM-1 in PVR suggests an impaired inflammatory response to retinal trauma.
  • Persistently high vitreous sICAM-1 indicates ongoing cytokine-mediated vascular reactions at the blood-retinal barrier.