Myxoid liposarcoma of the retropatellar fat pad

Soft-tissue sarcomas are rare lesions, and they are occasionally seen by the orthopedic surgeon. We describe the clinical history of a patient with a myxoid liposarcoma that arose from the retropatellar fat pad of the knee. The differential diagnosis of knee masses and the magnetic resonance image characteristics of myxoid liposarcoma are discussed. There are no previous reports of liposarcomas originating from the retropatellar fat pad. Given the consequences of inappropriate biopsy and surgery of suspected benign lesions, it is fundamentally important to adhere to the principles of musculoskeletal oncology in the evaluation of any soft-tissue mass that could be malignant.