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Related Experiment Videos

Left ventricular size and function in elite bodybuilders using anabolic steroids

R D Dickerman1, F Schaller, N Y Zachariah

  • 1Department of Biochemistry & Molecular Biology, University of North Texas Health Science Center, Fort Worth 76107-2609, USA.

Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine
|April 1, 1997
PubMed
Summary

Anabolic steroid use in bodybuilders may lead to increased left ventricular hypertrophy and decreased compliance. However, cardiac function appears unaffected, with no direct evidence of diastolic dysfunction.

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Area of Science:

  • Cardiology
  • Exercise Physiology
  • Pharmacology

Background:

  • Resistance training is common among competitive bodybuilders.
  • Anabolic steroid use is prevalent in this population.
  • The impact of anabolic steroids on cardiac structure and function requires investigation.

Purpose of the Study:

  • To examine the relationship between anabolic steroid use and left ventricular function in competitive bodybuilders.
  • To compare cardiac parameters between drug-free and anabolic steroid-using bodybuilders.

Main Methods:

  • Echocardiography was performed on 16 competitive heavyweight bodybuilders.
  • Subjects were divided into drug-free (DF) and anabolic steroid-using (DU) groups (n=8 each).
  • Cardiologists and technicians were blinded to subjects' drug status.

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Main Results:

  • Body mass indexes (BMI) were similar between groups.
  • Anabolic steroid users (DU) showed increased left ventricular posterior wall and septal thickness (p < 0.05).
  • Left ventricular end-diastolic dimension indexed to BMI was smaller in the DU group (p < 0.05), indicating disproportionate wall thickening relative to chamber size.

Conclusions:

  • Anabolic steroid use may promote concentric left ventricular hypertrophy.
  • This hypertrophy may be associated with decreased ventricular compliance.
  • No direct evidence of diastolic dysfunction was detected by mitral inflow velocity patterns.