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Corneal endothelial changes after laser in situ keratomileusis
J J Pérez-Santonja1, H F Sakla, F Gobbi
1Alicante Institute of Ophthalmology, University of Alicante School of Medicine, Spain.
Journal of Cataract and Refractive Surgery
|March 1, 1997
Summary
Laser in situ keratomileusis (LASIK) for high myopia does not harm the corneal endothelium. Improvements in cell density after LASIK are linked to discontinuing contact lens wear.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Excimer Laser Applications
Background:
- High myopia correction using laser in situ keratomileusis (LASIK) is a common refractive procedure.
- Understanding the impact of LASIK on corneal endothelium health is crucial for patient outcomes.
Purpose of the Study:
- To evaluate in vivo changes in the human corneal endothelium after 193 nm excimer laser LASIK for high myopia.
- To assess endothelial cell density, cell size variation, and hexagonality at 3 and 6 months post-surgery.
Main Methods:
- Specular microscopy of the central corneal endothelium was performed preoperatively and postoperatively.
- The study included 33 eyes of 19 patients undergoing LASIK for high myopia.
- Patients were categorized into contact lens wearers and non-wearers for comparative analysis.
Main Results:
- No significant endothelial damage was observed following LASIK surgery.
- A significant increase in endothelial cell density and a decrease in cell size variation were noted at 6 months post-LASIK.
- These postoperative improvements were correlated with the cessation of contact lens use.
Conclusions:
- Excimer laser LASIK for high myopia is safe for the corneal endothelium.
- Observed improvements in endothelial parameters post-LASIK are primarily attributed to the discontinuation of contact lens wear.