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Relationship between plaque mass and neointimal hyperplasia after stent placement in Yucatan micropigs
B J de Smet1, R E Kuntz, Y J van der Helm
1Heart Lung Institute, Utrecht University Hospital, The Netherlands.
Purpose:
To determine whether the amount of neointima found after stent placement is related to the preexistent plaque mass in the peripheral arteries in micropigs.
Materials And Methods:
Twenty-six peripheral arteries were studied in 14 Yucatan micropigs in a denudation and diet-induced atherosclerosis model. Quantitative angiographic and intravascular ultrasound (US) analysis were performed before and after stent placement and at follow-up 6 weeks after stent placement. At follow-up, the peripheral arterial tree was fixed by means of pressure perfusion, processed for histologic analysis, and analyzed morphometrically with a computer-based system.
Results:
Preexistent plaque correlated strongly with intimal hyperplasia measured on US images (r = .81, P < .001) or in histologic sections (r = .53, P = .006). No correlation was found between dilation ratio and intimal hyperplasia or between balloon-to-lesion ratio and intimal hyperplasia. In multivariate models of intimal hyperplasia, preexistent plaque and early gain in lumen diameter depicted at angiography were independent explanatory variables.
Conclusion:
The amount of plaque present before stent placement was a determinant of the amount of intimal hyperplasia present after stent placement.