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Predisposition testing for breast and ovarian cancer susceptibility
1Cancer Risk Evaluation Program, University of Pennsylvania Cancer Center, Philadelphia 19104, USA.
Seminars in Oncology Nursing
|May 1, 1997
Summary
Genetic testing for inherited breast cancer risk is crucial. Nurses need to understand genetic testing implications, including gene analysis, risks, benefits, and management for mutation carriers.
Area of Science:
- Oncology
- Genetics
- Nursing
Background:
- Breast cancer predisposition syndromes are linked to specific inherited gene alterations.
- Identifying these genetic alterations is key for risk assessment and management.
Purpose of the Study:
- To review current knowledge on breast cancer predisposition syndromes and susceptibility genes.
- To outline the clinical implications of genetic testing for hereditary breast and ovarian cancer.
Main Methods:
- Literature review of published research, educational manuscripts, and conference proceedings.
- Inclusion of personal experiences and expert knowledge.
Main Results:
- Numerous breast and ovarian cancer susceptibility genes have been identified.
- Genetic testing provides critical information for individuals with increased hereditary cancer risk.
Conclusions:
- Nurses require comprehensive knowledge of genetic testing for inherited breast cancer risk.
- This includes understanding gene-specific risks, testing indications, limitations, management of carriers, and psychosocial impacts.
- Nurses are pivotal in providing genetic services, encompassing practice, education, research, and policy.