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Related Experiment Videos

An inherited platelet function defect in a Simmental crossbred herd

P A Gentry1, L A Cheryk, R D Shanks

  • 1Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph.

Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire
|April 1, 1997
PubMed
Summary

A novel inherited bleeding disorder similar to Simmental hereditary thrombopathy (SHT) was found in cattle. Affected calves showed significantly reduced platelet aggregation, with some heterozygotes identified for the first time.

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Area of Science:

  • Veterinary Medicine
  • Hematology
  • Animal Genetics

Background:

  • An inherited bleeding disorder resembling Simmental hereditary thrombopathy (SHT) was identified in a Simmental crossbred herd.
  • Affected animals exhibited abnormal platelet function, specifically impaired aggregation responses.

Purpose of the Study:

  • To characterize a novel inherited bleeding disorder in Simmental cattle.
  • To identify heterozygous carriers of the condition based on platelet aggregation tests.

Main Methods:

  • Platelet aggregation assays using adenosine-diphosphate (ADP) and platelet activating factor (PAF16) as agonists.
  • Coagulation profile analysis.
  • Clinical evaluation of affected calves.

Main Results:

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  • An affected bull calf showed an absent platelet aggregation response to ADP and a 70% reduction to PAF16.
  • Six out of 18 offspring of a suspected carrier sire exhibited partially impaired platelet aggregation (approx. 50% of normal).
  • One heifer calf with impaired aggregation had reduced Factor XI levels and suffered fatal hemorrhage.

Conclusions:

  • This study identified a novel inherited bleeding disorder in Simmental cattle, distinct from previously described thrombopathies.
  • The findings suggest the possibility of identifying heterozygous carriers of Simmental hereditary thrombopathy (SHT) through in vitro platelet aggregation testing with ADP.