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T-cell receptors: is the repertoire inherently MHC-specific?
C A Janeway1, A V Chervonsky, D Sant'Angelo
1Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut, 06520-8011, USA.
Current Biology : CB
|May 1, 1997
Abstract:
A debate over whether the observed specificity of the naive T-cell receptor repertoire for major histocompatibility complex molecules arises before or after selection within the thymus has apparently been settled in favour of the former by a series of new experiments.