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Chromatin remodeling and transcription
1Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 5E-26, Bethesda, Maryland, 20892-4255, USA.
Current Opinion in Genetics & Development
|April 1, 1997
Summary
Chromatin remodeling involves SWI2/SNF2 family proteins and histone acetylation/deacetylation enzymes. These systems, regulated by conserved transcriptional regulators, are crucial for gene expression.
Area of Science:
- Molecular Biology
- Epigenetics
- Gene Regulation
Background:
- Two key chromatin remodeling systems regulate transcription.
- These include the SWI2/SNF2 family and histone acetylating/deacetylating enzymes.
Purpose of the Study:
- To highlight recent advances in understanding these chromatin remodeling systems.
- To identify the catalytic subunits and transcriptional roles of these systems.
Main Methods:
- Analysis of conserved proteins involved in chromatin remodeling.
- Genetic identification of transcriptional regulators.
Main Results:
- SWI2/SNF2 family proteins possess ATP-dependent nucleosome destabilizing activity.
- Enzymatic systems control histone acetylation and deacetylation.
- Catalytic subunits of these systems are conserved transcriptional regulators.
Conclusions:
- Chromatin remodeling is essential for transcriptional regulation.
- Conserved proteins act as transcriptional regulators through chromatin modification.