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Life and death in the cytoplasm: messages from the 3' end
M Wickens1, P Anderson, R J Jackson
1Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, 53706, USA. wickens@biochem.wisc.edu
Current Opinion in Genetics & Development
|April 1, 1997
Abstract:
The cytoplasmic life of an mRNA revolves around the regulation of its localization, translation and stability. Interactions between the two ends of the mRNA may integrate translation and mRNA turnover. Regulatory elements in the region between the termination codon and poly(A) tail - the 3' untranslated region - have been identified in a wide variety of systems, as have been some of the key players with which these elements interact.