Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure and function of vav

F Romero1, S Fischer

  • 1Institut Cochin de Génétique Moléculaire, U363 INSERM, Hôpital Cochin, Paris, France.

Cellular Signalling
|December 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pesticide residues alter taxonomic and functional biodiversity in soils.

Nature·2026
Same author

Accumulation of polyethylene microplastics in river biofilms and effect on the uptake, biotransformation and toxicity of the antimicrobial triclosan.

Environmental pollution (Barking, Essex : 1987)·2024
Same author

Perspectives on scientific error.

Royal Society open science·2023
Same author

A guideline to frame stressor effects in freshwater ecosystems.

The Science of the total environment·2021
Same author

Effects of convective drying assisted by ultrasound and osmotic solution on polyphenol, antioxidant and microstructure of murtilla (<i>Ugni molinae</i> Turcz) fruit.

Journal of food science and technology·2021
Same author

EDIL3 promotes epithelial-mesenchymal transition and paclitaxel resistance through its interaction with integrin α<sub>V</sub>β<sub>3</sub> in cancer cells.

Cell death discovery·2020
Same journal

Diosgenin alleviates radiation nephropathy by suppressing renal mTORC1 signalling with concomitant effects on the gut and liver.

Cellular signalling·2026
Same journal

Glycine induces MafG to regulate glutathione metabolism, inhibit chondrocyte ferroptosis, and upregulate plectin to improve osteoarthritis.

Cellular signalling·2026
Same journal

SHC4 suppresses ferroptosis and promotes sorafenib resistance in hepatocellular carcinoma by disrupting the interaction between NCOA4 and FTH1.

Cellular signalling·2026
Same journal

Post-translational modifications in triple-negative breast cancer: research status and translation challenges.

Cellular signalling·2026
Same journal

PDK4-dependent lactate production and lactylation promote renal calcium oxalate crystal-induced EMT and mitochondrial dysfunction via the TGF-β/SMAD3/GPX4 axis.

Cellular signalling·2026
Same journal

O-GlcNAcylation-mediated glycolytic reprogramming of CD4<sup>+</sup> T cells contributes to type H vessel impairment in diabetic osteoporosis.

Cellular signalling·2026
See all related articles

The proto-oncogene vav is crucial for T and B cell activation and proliferation. This review summarizes current knowledge on vav

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Signaling

Background:

  • The proto-oncogene vav is exclusively expressed in hematopoietic cells.
  • A widely expressed homologue, vav2, has been identified.
  • Vav possesses multiple domains (e.g., SH2, SH3, Dbl-homology, PH) implicated in protein interactions and signaling.

Purpose of the Study:

  • To review current knowledge on the vav proto-oncogene.
  • To evaluate the roles of vav in cellular functions, particularly in hematopoietic cells.

Main Methods:

  • Review of existing literature on vav.
  • Analysis of structural domains and their functions.
  • Examination of tyrosine phosphorylation patterns.
  • Consideration of knockout studies (vav-/-).

Related Experiment Videos

Main Results:

  • Vav contains numerous signaling-associated domains, suggesting a role in signal transduction.
  • Vav undergoes rapid tyrosine phosphorylation upon activation of various receptors, cytokines, and growth factors.
  • Vav knockout studies demonstrate its essential role in T and B cell proliferation and activation.

Conclusions:

  • Vav is a key signaling molecule in hematopoietic cells.
  • Vav plays an indispensable role in lymphocyte activation and proliferation.