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Etretinate may work where acitretin fails
T O Bleiker1, J F Bourke, R A Graham-Brown
1Department of Dermatology, Leicester Royal Infirmary, U.K.
The British Journal of Dermatology
|March 1, 1997
Abstract:
Acitretin (Ro 10-1670, Neotigason), a second-generation monoaromatic retinoid, is the main acid derivative and active metabolite of etretinate (Ro 10-9359, Tigason). Three patients who were unresponsive to treatment with acitretin but who responded to etretinate are reported. Twenty-nine patients in the U.K. are currently receiving etretinate on a named-patient basis. Possible explanations for the functional discrepancy between the two drugs are discussed.