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Etretinate may work where acitretin fails

T O Bleiker1, J F Bourke, R A Graham-Brown

  • 1Department of Dermatology, Leicester Royal Infirmary, U.K.

The British Journal of Dermatology
|March 1, 1997
PubMed
Summary

Acitretin, a retinoid, is the metabolite of etretinate. Some patients unresponsive to acitretin responded to etretinate, suggesting a functional discrepancy between these related drugs.

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Area of Science:

  • Dermatology
  • Pharmacology
  • Retinoid Therapy

Background:

  • Acitretin is a second-generation monoaromatic retinoid.
  • It is the primary acid derivative and active metabolite of etretinate.
  • Retinoids are crucial in treating various skin conditions.

Observation:

  • Three patients demonstrated unresponsiveness to acitretin treatment.
  • These same patients showed positive responses when treated with etretinate.
  • This highlights a potential difference in clinical efficacy.

Findings:

  • A functional discrepancy exists between acitretin and etretinate.
  • This suggests varying patient responses to closely related retinoid compounds.
  • Further investigation into the pharmacodynamics is warranted.

Implications:

  • Patient management may require considering etretinate for those unresponsive to acitretin.
  • Understanding retinoid metabolism and action is critical for therapeutic success.
  • This finding could influence future retinoid drug development and prescription guidelines.

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