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cDNA sequence and chromosomal localization of the NDUFS8 human gene coding for the 23 kDa subunit of the
V Procaccio1, D Depetris, P Soularue
1Laboratoire BECP/EA 2019 UJF-DBMS, CEA Grenoble, France. procaccio@homme.ceng.cea.fr
Biochimica Et Biophysica Acta
|March 20, 1997
Abstract:
We have sequenced the cDNA for the 23 kDa subunit of the human mitochondrial respiratory complex I. The deduced protein consists of 210 amino acids (Mr = 23705 Da) with a 34 amino acid N terminus presumably acting as a presequence for mitochondrial import. The predicted mature protein (Mr = 20290 Da) is 92% identical to the bovine mitochondrial subunit and 72% to the Rhodobacter capsulatus NUOI counterpart. Two clusters of four cysteine residues are conserved among these proteins. The gene (NDUFS8) coding for the human subunit has been mapped to chromosome 11q13.