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Related Experiment Videos

Discrepancies in normative data between Lunar and Hologic DXA systems

K G Faulkner1, L A Roberts, M R McClung

  • 1Oregon Osteoporosis Center, Portland 97213, USA.

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
|January 1, 1996
PubMed
Summary

Comparing bone mineral density (BMD) T-scores from Lunar and Hologic DXA systems revealed discrepancies, particularly at the femoral neck. Recalibrating T-scores using updated normative data resolved these differences, ensuring consistent osteoporosis assessment.

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Area of Science:

  • Osteoporosis diagnostics
  • Bone mineral density (BMD) assessment
  • Dual-energy X-ray absorptiometry (DXA) technology

Background:

  • DXA scanners from Lunar and Hologic show high BMD correlation but differ in absolute calibration.
  • Clinical fracture risk assessment relies on T-scores, not raw BMD values (g/cm2).
  • World Health Organization (WHO) diagnostic criteria for osteoporosis are based on T-scores.

Purpose of the Study:

  • To compare T-scores between Lunar and Hologic DXA systems.
  • To investigate discrepancies in T-scores and their causes.
  • To develop a method for harmonizing T-score measurements between manufacturers.

Main Methods:

  • Linear regression analysis was used to compare T-scores from Lunar DPX and Hologic QDR-1000/W systems in women.

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  • T-scores were analyzed for the L1-4 vertebrae and femoral neck.
  • Femoral neck T-scores were recalculated using revised normative data derived from NHANES and cross-calibration equations.

    • Main Results:

    • BMD and T-score measurements were highly correlated (r > 0.95) between systems.
    • No significant difference in L1-4 T-scores was observed (<0.1 SD).
    • A systematic difference of 0.9 SD was found in femoral neck T-scores, attributed to differing normative populations and statistical models.

    Conclusions:

    • Discrepancies in femoral neck T-scores between Lunar and Hologic DXA systems exist due to variations in normative data and statistical methods.
    • Recalibration of femoral neck T-scores using adjusted normative values (Hologic: 0.85 ± 0.11 g/cm2; Lunar: 1.00 ± 0.11 g/cm2) effectively eliminated inter-manufacturer discrepancies.
    • Further validation in young normal adults is recommended to confirm the revised T-score values.