Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Impulsivity and serotonergic function in compulsive personality disorder

D J Stein1, R L Trestman, V Mitropoulou

  • 1Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.

The Journal of Neuropsychiatry and Clinical Neurosciences
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Family History and Solar Insolation in Bipolar I Disorder.

Acta psychiatrica Scandinavica·2026
Same author

Exploring the relationships between Early Childhood Adversity, Social Cognition, and Aggression in a South African Study of People Living with Schizophrenia.

Schizophrenia research. Cognition·2025
Same author

Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study.

bioRxiv : the preprint server for biology·2025
Same author

Systematic review of genome-wide association studies (GWAS) of epilepsy identifies common risk variants and associated genes.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2024
Same author

Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents.

Human brain mapping·2024
Same author

Global cross-cultural validation of a brief measure for identifying potential suicide risk in 42 countries.

Public health·2024

Compulsive personality disorder is linked to impulsive aggression and blunted prolactin responses, suggesting a complex relationship with serotonergic dysfunction in males.

Area of Science:

  • Neurobiology
  • Psychiatry
  • Clinical Psychology

Background:

  • Investigating the neurobiological underpinnings of personality disorders is crucial for understanding complex behavioral patterns.
  • Serotonergic dysfunction has been implicated in various psychiatric conditions, including personality disorders.

Observation:

  • This study assessed serotonergic function via prolactin response to fenfluramine in males with compulsive personality disorder, noncompulsive personality disorders, and healthy controls.
  • Patient groups were comparable in age, depression, suicide history, and borderline personality disorder comorbidity.

Findings:

  • Males with compulsive personality disorder exhibited significantly higher impulsive aggression scores compared to those with noncompulsive personality disorders.
  • Compulsive personality disorder patients showed significantly blunted prolactin responses, indicating impaired serotonergic function, compared to both noncompulsive patients and controls.

Related Experiment Videos

  • In patients, compulsive personality disorder traits positively correlated with impulsive aggression and inversely with prolactin response.

    • Implications:

    • These findings challenge a simple dichotomy between impulsive and compulsive symptoms, suggesting a complex interplay.
    • The results support a link between compulsive personality traits, impulsive aggression, and serotonergic dysfunction.
    • This research may inform novel therapeutic strategies targeting serotonergic pathways for personality disorders characterized by impulsivity and compulsivity.