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Differential associations of P300 amplitude and latency with cognitive and psychiatric function in solvent-exposed
L A Morrow1, S R Steinhauer, R Condray
1Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA, USA.
The Journal of Neuropsychiatry and Clinical Neurosciences
|October 1, 1996
Abstract:
Cognitive and mood changes are central components of solvent encephalopathy. This study examined event-related potentials in relation to neuropsychological and psychiatric function in solvent-exposed adults. Results revealed that longer P300 latency was associated with poorer cognitive test scores, whereas reduced P300 amplitude was related to increased psychiatric symptomatology. The findings suggest that the cognitive deficits and the psychiatric disturbance following solvent exposure may have different neurophysiological bases.