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Related Experiment Videos

Partial angle closure

R Mapstone

    The British Journal of Ophthalmology
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Provocative tests for closed-angle glaucoma reveal that reduced outflow facility is linked to partial-angle closure. Peripheral iridectomy normalizes responses, confirming this mechanism in glaucoma patients.

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    Area of Science:

    • Ophthalmology
    • Glaucoma Research
    • Ocular Physiology

    Background:

    • Provocative tests are used to diagnose glaucoma.
    • Pharmacological agents like pilocarpine and phenylephrine can induce changes in intraocular pressure and outflow facility.
    • Partial-angle closure is a potential mechanism in glaucoma development.

    Purpose of the Study:

    • To investigate the cause of reduced outflow facility during provocative testing for closed-angle glaucoma.
    • To determine if partial-angle closure explains the observed changes in outflow facility.
    • To evaluate the efficacy of peripheral iridectomy in normalizing responses to provocative testing.

    Main Methods:

    • Administered pilocarpine and phenylephrine provocative tests to eyes.
    • Monitored outflow facility during provocative testing.

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  • Performed peripheral iridectomy on a subset of eyes with abnormal responses.
  • Re-tested eyes post-iridectomy.
  • Compared responses of eyes with and without prior iridectomy for closed-angle glaucoma.

    • Main Results:

    • 60% of eyes showed significant reductions in outflow facility during provocative testing.
    • Eyes with abnormal responses that underwent peripheral iridectomy normalized their outflow facility upon re-testing.
    • Eyes with a history of peripheral iridectomy for closed-angle glaucoma responded normally to provocative testing.

    Conclusions:

    • Reduced outflow facility during provocative testing is indicative of partial-angle closure.
    • Peripheral iridectomy effectively resolves the partial-angle closure, normalizing the eye's response to provocative stimuli.
    • This study supports partial-angle closure as a key factor in induced and spontaneous closed-angle glaucoma.