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Multicystic encephalomalacia in term infants
G Frigieri1, B Guidi, S Costa Zaccarelli
1Department of Gynaecological, Obstetric and Paediatric Sciences, University of Modena, Italy.
Summary
Subcortical leucomalacia (SCL) involves brain lesions from severe asphyxia or hypotension. This study documents SCL in eight newborns using ultrasonography, highlighting clinical-neurological alterations.
Area of Science:
- Neonatal Neurology
- Pediatric Radiology
- Neuroscience
Background:
- Multicystic encephalomalacia and subcortical leucomalacia (SCL) describe brain necrosis evolving into cystic lesions.
- These lesions are typically caused by severe asphyxia and/or hypotension in newborns.
- SCL designation can specify lesion extent, location, and differentiate from periventricular lesions.
Purpose of the Study:
- To report on the clinical and ultrasonographic findings of SCL in a cohort of newborns.
- To document the experience with eight neonates presenting with SCL.
Main Methods:
- Case series of eight newborns admitted to a neonatal intensive care unit.
- Clinical-neurological assessment of neonates.
- Ultrasonography to document encephalomalacic lesions.
Main Results:
- Eight newborns presented with clinical-neurological alterations consistent with encephalomalacia.
- Ultrasonography confirmed the presence of encephalomalacic lesions in all eight neonates.
- The study details the specific clinical and imaging findings observed.
Conclusions:
- Subcortical leucomalacia is a significant finding in neonates experiencing severe perinatal insults.
- Ultrasonography is a valuable tool for diagnosing and characterizing SCL in newborns.
- Early identification and documentation of SCL are crucial for understanding neonatal brain injury.