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Updated: Oct 2, 2026
OP-IVM: Combining In vitro Maturation after Oocyte Retrieval with Gynecological Surgery
Published on: May 9, 2021
Intravenous albumin prevents moderate-severe ovarian hyperstimulation in in-vitro fertilization patients: a
A Z Isik1, O Gokmen, H B Zeyneloglu
1Reproductive Endocrinology and IVF Unit, Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
Objective:
To assess the effectiveness of intravenous administration of albumin in prevention of ovarian hyperstimulation syndrome (OHSS) in patients of an in-vitro fertilization program.
Study Design:
Prospective randomized study. Patients with hCG day E2 levels are 11010 pmol/l (3000 pg/ml) or more were recruited into two groups. Group A (n = 27) received 10 g 20%, 50 ml human albumin infusion before oocyte pick-up and no medication was administered in Group B (n = 28).
Results:
Patients were similar in terms of cycle characteristics. No moderate-severe OHSS developed in Group A whereas one severe OHSS case and four moderate OHSS cases developed in Group B. Statistical analysis revealed a significant (P < 0.05) protection in albumin treated group.
Conclusion:
Human albumin proves effectiveness in prevention of moderate-severe OHSS.
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