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alpha-Tocopheryl quinone is converted into vitamin E in man

A N Moore¹, K U Ingold

¹Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario, Canada.

Free Radical Biology & Medicine

|January 1, 1997

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This study shows that alpha-tocopheryl quinone can be converted to alpha-tocopherol in humans after oral administration. While the overall yield is low, the conversion may be efficient for absorbed quinone.

Area of Science:

Biochemistry
Human Metabolism
Nutritional Science

Background:

Alpha-tocopheryl quinone is a metabolite of alpha-tocopherol (Vitamin E).
Understanding the interconversion of tocopheryl quinone and tocopherol is crucial for Vitamin E metabolism research.

Purpose of the Study:

To investigate the in vivo conversion of orally administered alpha-tocopheryl quinone to alpha-tocopherol in humans.
To quantify the extent of this conversion in human plasma.

Main Methods:

A single male subject received an oral dose of 400 mg alpha-tocopheryl quinone.
Plasma samples were analyzed 15 hours post-dose.
Analysis involved lipid extraction followed by Gas Chromatography-Mass Spectrometry (GC-MS) with single ion monitoring.

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Main Results:

Alpha-tocopherol was detected in plasma at a concentration of 0.4 microM.
This represented 0.8% of the total tocopherol in the plasma sample.
The results indicate a low overall yield of conversion from ingested quinone to plasma tocopherol.

Conclusions:

Oral administration of alpha-tocopheryl quinone results in its conversion to alpha-tocopherol in humans.
The overall conversion yield is low, but the efficiency of conversion for the absorbed portion of the quinone may be higher.