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Plasma selenium in healthy man before and after nutratherapy

J Karlsson1, G Lundgren, R Rønneberg

  • 1OBLA AB, Vaxholm, Sweden.

International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition
|January 1, 1997
PubMed
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Plasma selenium levels were positively associated with ubiquinone and vitamin E. Omega-3 fatty acid supplementation significantly increased selenium, suggesting a role for omega-3s in selenium status.

Area of Science:

  • Nutritional biochemistry
  • Human physiology
  • Dietary supplementation

Background:

  • Plasma selenium (Se), ubiquinone, alpha-tocopherol (vitamin E), and essential fatty acids (EFAs) are crucial nutrients.
  • Understanding the interrelationships between these nutrients is important for assessing nutritional status.

Purpose of the Study:

  • To investigate the relationships between plasma selenium, ubiquinone, alpha-tocopherol, and essential fatty acids (omega-3 and omega-6).
  • To evaluate the effects of nutritional supplementation (nutratherapy) with lipophilic antioxidants and omega-3 fatty acids on plasma selenium levels.

Main Methods:

  • Plasma samples from 67 participants (28 females, 39 males) were analyzed for selenium, ubiquinone, alpha-tocopherol, omega-3, and omega-6 fatty acids.
  • Participants received different food supplement regimens: ubiquinone + alpha-tocopherol (Q + E), or Q + E + omega-3 fatty acids (Q + E + n-3).

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  • Plasma nutrient levels were measured before and after supplementation, and correlations were analyzed.

    • Main Results:

    • Baseline plasma selenium showed a positive correlation with ubiquinone, alpha-tocopherol, and the omega-6/omega-3 ratio.
    • Supplementation with (Q + E) did not affect selenium levels.
    • Supplementation with (Q + E + n-3) significantly increased plasma selenium by 36% (p < 0.001).
    • Adding selenium to supplements raised levels, but not beyond the effect of (Q + E + n-3) alone.
    • Post-(Q + E + n-3) supplementation, selenium remained correlated only with ubiquinone, suggesting altered nutrient interactions.

    Conclusions:

    • Omega-3 fatty acid supplementation, particularly from fish oil concentrates, significantly enhances plasma selenium levels.
    • The interaction between selenium and essential fatty acids appears complex and may be influenced by other co-administered nutrients like ubiquinone and alpha-tocopherol.
    • Further research is needed to elucidate the mechanisms behind omega-3's effect on selenium status and the role of alpha-tocopherol in this interaction.