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Cortisol and catecholamine kinetics during continuous hemodiafiltration in patients with multiple organ dysfunction
T Tsubo1, Y Hashimoto, I Araki
1Intensive care Unit, University of Hirosaki, School of Medicine, Aomori-ken, Japan.
Objective:
To assess the influence of continuous hemodiafiltration (CHDF) on cortisol and catecholamine kinetics in multiple organ dysfunction syndrome.
Design:
Consecutive clinical study.
Setting:
General intensive care unit of a university hospital.
Patients:
Ten adult patients with multiple organ dysfunction syndrome requiring CHDF.
Measurements And Results:
A total of 40 samples were collected during CHDF for cortisol and catecholamine assays. The clearances for cortisol, epinephrine, norepinephrine and dopamine were 2.5 +/- 1.7 ml/min, 26.3 +/- 2.7 ml/min, 16.7 +/- 4.2 ml/min and 26.3 +/- 2.6 ml/min (Mean +/_ SE), and their daily extractions were 1.8 +/- 0.2 mg/day, 11.4 +/- 4.8 micrograms/day, 1.0 +/- 0.1 micrograms and 2.3 +/- 0.3 micrograms/day, respectively. There were no significant changes in blood cortisol and catecholamine levels during CHDF conducted for 48 h.
Conclusions:
The cortisol and catecholamine losses during CHDF were small and unlikely to lead to hemodynamic disturbances.