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Related Experiment Videos

Dystonia in progressive supranuclear palsy

C L Barclay1, A E Lang

  • 1University of Ottawa, Ottawa Civic Hospital, Ontario, Canada.

Journal of Neurology, Neurosurgery, and Psychiatry
|April 1, 1997
PubMed
Summary

Dystonia is a common symptom in progressive supranuclear palsy (PSP), particularly limb dystonia. Careful review of medications is advised, as some symptoms may be treatment-induced.

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Area of Science:

  • Neurology
  • Movement Disorders

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disease.
  • Dystonic symptoms are not well-characterized in PSP.

Purpose of the Study:

  • To document the nature, distribution, and frequency of dystonic symptoms in progressive supranuclear palsy (PSP).

Main Methods:

  • Reviewed charts and videotapes of clinically diagnosed PSP patients (1983-1993).
  • Recorded occurrence, nature, and distribution of dystonic symptoms.

Main Results:

  • 38 out of 83 (46%) PSP cases exhibited dystonic features.
  • Common symptoms included blepharospasm (24%), limb dystonia (27%), and axial dystonia (17%).
  • Limb dystonia sometimes presented early, leading to misdiagnosis; concurrent diseases were noted in some cases.

Conclusions:

  • Dystonia is a frequent manifestation of PSP.
  • Limb dystonia may suggest co-existing conditions.
  • Consider reducing or discontinuing dopaminergic medication to rule out treatment-induced dystonia.

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