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Prognosis of tuberculous meningitis: a multivariate analysis
U K Misra1, J Kalita, M Srivastava
1Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Journal of the Neurological Sciences
|April 1, 1996
Summary
Prognostic factors for tuberculous meningitis (TBM) were identified. Stage of TBM, age, focal weakness, cranial nerve palsy, and hydrocephalus significantly predict three-month outcomes in TBM patients.
Area of Science:
- Neurology
- Infectious Diseases
- Medical Imaging
Background:
- Tuberculous meningitis (TBM) is a severe infection with variable outcomes.
- Identifying prognostic factors is crucial for patient management and treatment strategies.
Purpose of the Study:
- To identify clinical, laboratory, and CT scan features that predict the three-month outcome in patients with TBM.
- To develop a prognostic model for TBM.
Main Methods:
- Analysis of 26 features in 49 TBM patients.
- Univariate analysis to identify initial correlating variables.
- Conditional logistic regression model incorporating all variables.
Main Results:
- Seven variables correlated with outcome in univariate analysis: TBM stage, focal weakness, Glasgow Coma Scale (GCS), incontinence, infarction, hydrocephalus, and shunt surgery.
- The logistic regression model identified TBM stage, age, focal weakness, cranial nerve palsy, and hydrocephalus as significant predictors of three-month outcome.
Conclusions:
- TBM stage, age, focal weakness, cranial nerve palsy, and hydrocephalus are key predictors of short-term outcomes in TBM.
- These factors can aid in assessing prognosis and guiding clinical decisions for TBM patients.