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Updated: Oct 21, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

[Gas exchange and hemodynamics following complete replacement of blood with a solution of purified hemoglobin]

N A Fedorov, V S Iarochkin, V B Koziner

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |October 1, 1977
    PubMed

    Complete exchange blood substitution (down to hematocrit level of 1--3%) by 7--8% solution of hemoglobin (Hb) completely free of stromas and procoagulant activity of human hemoglobin was performed in cats. The Hb solution is capable of carrying oxygen and maintaining the life of the animal with a complete blood loss for some time. The Hb solution is readily saturated with oxygen in the lungs and releases oxygen in the tissues, although to a significantly lesser degree than Hb in the red cell; besides, the Hb solution maintains the basic value of hemodynamics for some time.

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