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Related Experiment Videos

Tissue response to titanium plates: a transmitted electron microscopic study

Y K Kim1, H H Yeo, S C Lim

  • 1Department Of Oral and Maxillofacial Surgery, College of Dentistry, Chosun University, Kwang-Ju, Korea.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|April 1, 1997
PubMed
Summary
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Titanium miniplates can cause tissue damage, with particles found in surrounding bone and soft tissues. Routine removal after bone healing is recommended to prevent further complications.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Histopathology

Background:

  • Titanium implants are widely used in orthopedic surgery for bone fracture fixation.
  • Understanding the long-term tissue response to titanium implants is crucial for patient outcomes.

Purpose of the Study:

  • To investigate the tissue response and potential adverse effects associated with titanium miniplates used in fracture stabilization.
  • To evaluate the presence and location of titanium particles in surrounding tissues.

Main Methods:

  • Titanium miniplates were used in 14 patients for bone stabilization.
  • Macroscopic examination of osteosynthesis sites was performed.
  • Biopsies of surrounding soft and bony tissues were analyzed using light and transmission electron microscopy.

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Main Results:

  • Macroscopic pigmentation was observed in 14% of soft tissue samples.
  • Microscopic examination revealed pigmentation in 10/14 soft tissue sites and 1/2 bony sites.
  • Titanium particles were detected within connective tissue, fibroblasts, and macrophages, with associated degenerative changes in bone matrix.

Conclusions:

  • Titanium miniplates can induce local tissue destruction in both hard and soft tissues.
  • Prolonged presence of titanium plates may lead to cumulative tissue damage.
  • Routine removal of titanium miniplates after bone healing is advised to mitigate potential risks.