Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonfatal suicidal intoxication by clozapine

A Ishii1, K Mizoguchi, M Kageoka

  • 1Hamamatsu University School of Medicine, Japan.

Journal of Toxicology. Clinical Toxicology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of Allergic Bronchoconstriction in Guinea Pigs and in Asthmatics by the Leukotriene Antagonist ONO-1078.

International archives of allergy and immunology·2021
Same author

Direct detection of circular polarized light in helical 1D perovskite-based photodiode.

Science advances·2020
Same author

Surgical options in suprastomal collapse-induced severe airway obstruction.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2020
Same author

Decoding supraglottic stenosis.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2019
Same author

Erratum to: Training guidelines for endovascular stroke intervention: an international multi-society consensus document.

Neuroradiology·2017
Same author

Improvement of neurological disorders in postmenopausal model rats by administration of royal jelly.

Climacteric : the journal of the International Menopause Society·2016
Same journal

Ingestion of high-dose buprenorphine by a 4 year-old child.

Journal of toxicology. Clinical toxicology·2005
Same journal

A reassessment of topical organic phosphorus insecticide exposures and permanent paralysis.

Journal of toxicology. Clinical toxicology·2005
Same journal

Methamphetamine toxicity secondary to intravaginal body stuffing.

Journal of toxicology. Clinical toxicology·2005
Same journal

Duodenal perforation after ibuprofen overdose.

Journal of toxicology. Clinical toxicology·2005
Same journal

Delayed dystonia following pimozide overdose in a child.

Journal of toxicology. Clinical toxicology·2005
Same journal

Pattern of acute poisonings in Mashhad, Iran 1993-2000.

Journal of toxicology. Clinical toxicology·2005
See all related articles

A 23-year-old woman survived a clozapine overdose intended for suicide. Medical treatment led to recovery, with high clozapine levels detected in serum and urine.

Area of Science:

  • Pharmacology
  • Clinical Toxicology

Background:

  • Clozapine is an atypical antipsychotic used to treat schizophrenia.
  • Overdose can lead to serious toxicity, necessitating careful monitoring and management.

Observation:

  • A case of intentional clozapine overdose in a 23-year-old woman is reported.
  • The patient presented after ingesting a significant amount of clozapine with suicidal intent.

Findings:

  • Serum clozapine concentration peaked at 3.62 µg/mL three hours post-ingestion.
  • Urine clozapine concentration was 4.28 µg/mL thirty-two hours after ingestion.
  • Gas chromatography/mass spectrometry and nitrogen phosphorus detection were used for analysis.

Implications:

  • This case highlights the potential for severe toxicity with clozapine overdose.

Related Experiment Videos

  • Prompt medical intervention and supportive care are crucial for patient survival.
  • Accurate toxicological analysis is vital for managing clozapine intoxication.