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Updated: Aug 10, 2026
06:55
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
[Rheumatoid purpura during pregnancy]
C Le Goff1, C Chatelier, T Lobbedez
1Service de néphrologie, CHU Clémenceau, Caen.
Nephrologie
|January 1, 1997
Summary
A pregnant woman developed Henoch-Schönlein purpura and IgA glomerulonephritis. Despite treatment, she experienced nephrotic syndrome, fetal death, and end-stage renal failure.
Area of Science:
- Nephrology
- Obstetrics
- Immunology
Background:
- Henoch-Schönlein purpura (HSP) is a systemic vasculitis.
- IgA glomerulonephritis (IgA GN) is a common cause of primary glomerulonephritis.
- Pregnancy can alter the course of autoimmune and renal diseases.
Observation:
- A 26-year-old woman presented with HSP at 13 weeks' gestation.
- Renal biopsy confirmed IgA GN without adverse features.
- Nephrotic syndrome developed during pregnancy.
Findings:
- Corticosteroid therapy was ineffective for the nephrotic syndrome.
- Fetal death occurred at 25 weeks' gestation.
- Rapid progression to end-stage renal failure followed.
Implications:
- This case highlights the severe maternal and fetal risks of HSP and IgA GN during pregnancy.
- Management of renal disease in pregnancy requires careful consideration.
- Further research is needed on optimal therapeutic strategies for pregnant women with IgA GN.
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