[Relationship between some parameters of carbohydrate metabolism, proteinuria and glomerular filtration rate in...

It is very well known that carbohydrate metabolism disturbances may affect progression of renal disease in patients with moderate renal insufficiency. The aim of this study was to analyse the relationship between glucose, insulin and changes of creatinine clearance and proteinuria in patients with primary glomerulonephritis and normal renal function. Thirteen non-treated patients with primary glomerulonephritis, were given 75 g glucose orally and area under insulin and glucose curves were estimated. Afterwards all patients were followed-up for 17.6 +/- 3.1 months and none of them was subjected to any pharmacological intervention. At the end of the study neither proteinuria nor creatinine clearance changed significantly. But significant linear correlations were found between pre-follow-up glucose and insulin and changes of daily proteinuria (r = 0.632, p < 0.05; r = 0.538, 0.05 < p < 0.1) respectively. No correlations were found between insulin and glucose area and changes of creatinine clearance. Authors analyze the potential role of some factors linking the glucose metabolism and proteinuria.