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Orbital avitene granuloma formation after enucleation for intraocular retinoblastoma
1New York Hospital/Cornell Medical Center, NY, USA.
Purpose:
To report a case of orbital foreign body granuloma formation, mimicking tumor recurrence, secondary to the use of Avitene after enucleation for intraocular retinoblastoma.
Methods:
Eight months after undergoing enucleation for retinoblastoma, a 21-month-old boy underwent a biopsy of an orbital mass.
Results:
Histopathologic examination of the orbital biopsy specimen disclosed a proliferative granulomatous foreign body reaction surrounding multiple foci of a coarse fibrillar intercellular substance consistent with Avitene. No retinoblastoma cells were present.
Conclusion:
A foreign body reaction should be included in the differential diagnosis of orbital mass lesions after surgery in which Avitene is used.